沈元星:数字化全偏振病理检测系统设计及应用|SIGS优硕风采 | 图像( 二 )


2、对影响全偏振成像的两大因素——相机噪声及成像透镜误差进行了系统研究,并针对性地提出积分时间降噪法及成像透镜设计方案,提升了全偏振病理显微成像质量;研究了光学分辨率与不同偏振参数图像之间的关系,发现如线性相位延迟等信息可以通过相对低分辨率偏振成像结果获得,为偏振数字病理系统中物镜参数的选取提供了重要依据,有助于未来实现临床上快速的偏振扫描、检测与诊断。上述研究为提升全偏振数字病理系统的可靠性提供了保证;
3、初步展示了全偏振数字病理系统在实际病理检测中的应用前景,演示了全偏振数字病理技术与计算机图像及大数据分析技术结合的潜力。
学位论文相关学术成果
[1]Shen Y X, Huang R R, He H H, et al. Comparative study of the influence of imaging resolution on linear retardance parameters derived from the Mueller matrix[J]. Biomed Opt Express, 2021, 12(1):211-225.
[2]Shen Y X, He C, He H H et al. Polarization aberration in high numerical aperture lens system and its effect on vectorial information sensing[J].(已被special issue "polarization measurement and applications" on ISPRS Journal of Photogrammetry and Remote Sensing录用)
沈元星:数字化全偏振病理检测系统设计及应用|SIGS优硕风采 | 图像】[3]Shen Y X, Sheng W, He H H, et al. Assessing distribution features of fibrous structures using Mueller matrix derived parameters: a quantitative method for breast carcinoma tissues detection and staging[C]// Proc SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 2020, 112390F.
[4]沈元星, 姚悦, 何宏辉, 等. 非标记、定量化穆勒矩阵偏振成像在辅助临床诊断中的应用[J]. 中国激光, 2020, 47(2):0207001.
[5] Huang R R,Shen Y X, He H H, et al. Comparative study of influence of imaging resolution on Mueller matrix derived parameters[C]// Proc SPIE 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII, 2021, 116410A.
[6] Dong Y, Liu S X,Shen Y X, et al. Probing variations of fibrous structures during the development of breast ductal carcinoma tissues via Mueller matrix imaging[J]. Biomed Opt Express, 2020, 11(9):4960-4975.
[7] Chen B G, He H H, Zhu H Y et al, Assessing structural features of tuberculosis using Mueller matrix derived parameters: a quantitative method to distinguish between Crohn’s disease and gastrointestinal luminal tuberculosis[C]// Proc SPIE 11553, Optics in Health Care and Biomedical Optics X, 2020, 115530A.
来源|培养处
策划|陈金静、兑晓晴
文、图|沈元星
编辑|余飞慧
排版|姚诗诗
中文微信公众号:清华大学深圳国际研究生院
英文微信公众号:Tsinghua SIGS
新浪微博:@清华SIGS

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